Abstract

MOMORDICA CHARANTIA L. PLUS MELATONIN PRESENT AN EFFECTIVE IMMUNOMODULATORY EFFECT TO ELIMINATED ENTEROPATHOGENIC ESCHERICHIA COLI AND STREPTOCOCCUS PNEUMONIAE.

João Vitor Silva Ormonde, Rubian Trindade Silva Fernandes, Gabriel Triches Nunes, Edson Fredulin Scherer, Adenilda Cristina Honorio-França*, Eduardo Luzía França.

ABSTRACT

Momordica charantia L. is important plant species used for food and herbal medicines. Furthermore, melatonin hormone has also been shown to perform different actions on the cellular oxidative metabolism. This study aimed to verify the functional activity of mononuclear (MN) and polymorphonuclear PMN) phagocytes treated with Momordica charantia L. and melatonin in the presence of bacteria. Phagocytes of clinically healthy donors were exposed to stimulation of plant extract, bacteria – Enteropathogenic Escherichia coli (EPEC) and Streptococcus pneumoniae - and the hormone melatonin. The superoxide release by phagocytes was evaluated by the method of reduction of cytochrome C. The phagocytosis and microbicidal activity was observed using the method of acridine orange. It was revealed an increase (p

Keywords: Momordica charantia, immunomodulation, phagocytes, melatonin.