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SYNTHESIS, CHARACTERIZATION AND BIOLOGICAL EVALUATION oF NOVEL [1,2,4]TRIAZOLO[4,3-C]PYRIMIDIN-3- YL)BENZAMIDE POSSESSING TRI FLUOROMETHYL, FLUORO, NITRO AND MORPHOLINE, THIO MORPHOLINE MOIETIES
V. Prabhakar*, K. Sudhakar Babu, L.K. Ravindranath, J. Latha,
ABSTRACT Purpose: The article is aimed to synthesize, characterize and screening the biological activity of a series of N-(5-morpholino- [1,2,4]triazolo[4,3-0]pyrimidin-3-yl)-4-trifluoromethyl/Fluoro/Nitro/ methoxy) benzamide(7 a-h). Methods: The newly synthesized compounds were characterized by elemental analysis and IR, 1H-NMR, 13C NMR and Mass spectral data. The antimicrobial activity of the novel compounds was screened by agar disc diffusion method. Results: 7b, 7d,7a, 7c have shown better antibacterial and anti fungal activity than other compounds of the series. Pyrimidine linked Fused triazoles nucleus has shown good antibacterial and antifungal activities. Keywords: Morpholine, thiomorpholine, Triazoles, antibacterial and antifungal, [Download Article] [Download Certifiate] |