Abstract

DEVELOPMENT AND VALIDATION OF UV SPECTROPHOTOMETRIC ESTIMATION OF LISINOPRIL DIHYDRATE IN BULK AND TABLET DOSAGE FORM USING AREA UNDER CURVE METHOD.

Mali Audumbar Digambar*, Jadhav Santosh, Tamboli Ashpak, and Kargane Vijay.

ABSTRACT

A simple, precise, accurate, and economical UV visible spectrophotometric method has been developed for estimation of Lisinopril Dihydrate drug by AUC method. The standard and sample solutions were prepared by using double distilled water as a solvent. Quantitative determination of the drug was performed at wavelength range 202-216 nm. The linearity was established over the concentration range of 10-30 μg/ml for Lisinopril Dihydrate with correlation coefficient value of 0.9993. Precision studies showed that % relative standard deviation was within range of acceptable limits. The mean percentage recovery was found to be 99.905%. The proposed method has been validated as per ICH guidelines.

Keywords: Lisinopril Dihydrate, UV visible spectrophotometry, AUC, Method Validation.