Abstract

GASTROPROTECTIVE ACTIVITY OF CUCUMIS SATIVUS L

Vaijayanthimala Palanisamy*, Sureshkumar Shanmugam,
Sangameswaran Balakrishnan

ABSTRACT

The objective was to investigate antiulcer activity of Ethanol Extract of Cucumis sativus (EECS) on indomethacine induced experimental ulcer models. The anti - ulcer effect of EECS at 150 mg/kg were evaluated in indomethacine induced ulcer models using Albino rats compared with Ranitidine used as a standard drug. In the conditions of inhibition of release of gastric juice, hydrochloric acid and neutralization activity. The anti ulcer activity was noted after drug administration. All data were analyzed by one-way ANOVA followed by Dunnet test. A maximum anti ulcer activity was found at 150 mg/ kg of EECS, which was near equivalent to that of standard drug Ranitidine. Histopathological study of the stomach also exhibited almost normal architecture, when compared to Indomethacine treated group ingredients.

Keywords: Cucumis sativus L, Indomethacine, PUD and Ranitidine.