Abstract

FORMULATION AND EVALUATION OF SOLID SELF EMULSIFYING DRUG DELIVERY SYTEM OF VORICONAZOLE

C. Aparna*, Dr. Prathima Srinivas, Dr. K.S.K. Rao Patnaik

ABSTRACT

The aim of the present work was to prepare Self emulsifying drug delivery system (SEDDS) of lipophilic anti-fungal drug,Voriconazole for improving its solubility and bioavailability. Various oils, surfactants and co-surfactants were screened for their suitability in the formulation of SEDDS. Based on the solubility studies, Oleic acid was selected as oil phase, Tween20 as surfactant, PEG 600 as Co-surfactant. The prepared formulations were evaluated for parameters like drug content, percentage transmittance and centrifugation test. Pseudoternary phase diagrams were constructed to determine the Nanoemulsion area for each formulation. From the results, F7 (2:1) was found to be the optimized formulation as it exhibited rapid emulsification and required drug content. In order to increase the patient compliance, the liquid SEDDS were converted into solid dosage form by adsorbtion technique. The optimized formulation was added on to an adsorbent, Aerosil 200. The drug release from these optimized formulations, Solid Self emulsifying drug delivery systems (SSEDDS) was also studied and found to be better compared to the conventional dosage form. Our studies indicate that SSEDDS can be effectively formulated by adsorption technique. Voriconazole SEDDS with enhanced dissolution rate and bioavailability were successfully formulated and evaluated.

Keywords: Voriconazole, self emulsifying drug delivery system, Oleic acid, Tween 20, PEG 600, Aerosil 200.