Abstract

FORMULATION DEVELOPMENT AND EVALUATION OF SUSTAINED RELEASE MATRIX TABLET OF GLIPIZIDE USING SODIUM STEARYL FUMARATE AS NOVEL MATRIX FORMING AGENT

Rakesh Kumar Meel*, Lokesh Kumar and Virendra Singh

ABSTRACT

The present research work endeavor is directed towards formulation, development and evaluation of sustained release matrix tablet of glipizide using Sodium stearyl fumarate as a matrix forming agent. Which is used as a lubricant but due to its both hydrophilic & hydrophobic properties, it can be used as a matrix forming agent. On the basis of this we tried to develop a sustained release matrix tablet using different pH dependent substances like tartaric acid, sodium dihydrogen phosphate, disodium hydrogen phosphate, trisodium hydrogen phosphate and glipizide as a model drug. Nine formulations (F1-F9) of glipizide were prepared by wet granulation method. The formulations were evaluated for various pre compression and post compression parameters also in vitro release studies were carried out in 7.4 pH phosphate buffer using the USP Type 2 apparatus as per USP monograph. F6, F7, F8, F9 formulations were prepared by using different pH dependent substance like tartaric acid, sodium dihydrogen phosphate, disodium hydrogen phosphate and trisodium hydrogen phosphate respectively. Optimized formulation F7 prepared by using sodium dihydrogen phosphate exhibited best sustained release pattern among all formulations. The dissolution data and drug contain was found to be maximum in F7 formulation as 42.85%, 59.27%, 76.21% and 92.78% at 1 hour, 3 hour, 6 hour and 10 hour respectively.

Keywords: Glipizide, sodium stearyl fumarate, sustained release matrix tablet, sodium dihydrogen phosphate.