![]() |
|||||||||||||
|
All | Since 2019 | |
Citation | 5450 | 3969 |
h-index | 23 | 20 |
i10-index | 134 | 84 |
PHYTOCHEMICAL SCREENING AND IN VIVO ANTIPYRETIC ACTIVITY OF THE AQUEOUS EXTRACT FROM MUCUNA PRURIENS
Uma S*, G. Ariharasivakumar #, Tamilarasan M and P. Gurumoorthi@
ABSTRACT Background: The present study was designed and investigated the antipyretic activity of the aqueous extract of Mucuna pruriens seed (MPSE) in rats. Methods: Brewer’s yeast was used to induce fever in Wister rats which divided into four groups. The animal groups were administration of MPSE (200mg/kg and 400mg/kg, Paracetamol (reference standard, 150mg/kg) and 1% Tween 80(control) respectively. The rectal temperature of the rats was measured period of 5h. Result: Phytochemical screening was performed. MPSE (200mg/kg and 400mg/kg) was significantly decreased yeast induced pyrexia (p<0.05, p<0.01, p<0.001) respectively. Phytochemical analysis showed that the presence of alkaloids, tannins, phenols, flavanoids and saponins. Conclusion: The results indicate the aqueous extract of M.pruriens seed extract strongly significant antipyretic activity. Keywords: Antipyretic activity, Brewer’s yeast, Mucuna pruriens, Paracetamol, Phytochemical screening. [Download Article] [Download Certifiate] |