Abstract

FORMULATION AND EVALUATION OF ANTIEMETIC NASAL SPRAY OF LIMONENE

Vikas Bhatt *, Rajni Karakoti, Baby Bhatt, Arun Kumar Singh, Dinesh Kumar Sharma

ABSTRACT

The objective of present investigation was to isolate the phytochemical component, limonene from the peels of Citrus sinensis belonging to family Rutaceae and formulate anti-emetic nasal spray. Limonene loaded colloidal dispersion was prepared by using various polymers like HPMC, DSHOP, and surfactant as Tween 80. Further the formulation was evaluated for its clarity, pH, viscosity, pka, pump delivery, net content, and droplet diameters. Limonene was obtained by steam distillation method and subjected to its phytochemical screening and Pharmacopoeial procedures were used to study the, solubility, organoleptic properties, pH, viscosity, pka , pump delivery, net content, droplet diameters. The pH of the formulation was adjusted between 5.0-5.5 which is nonirritant for nasal delivery system. The result showed that the optimized formulation was found to be colorless, orange like odor and shows adhesive property. The adhesive property in the formulation is because of the presence of mucoadhesive polymer, which prolongs the effectiveness of dosages form by its mucoretentive effect onto the nasal mucosa. To evaluate the spray related property, a plastic spray container was selected and evaluated for the release of net content which was found to be 20 ml and total spray pattern of the formulation was found to be 322 sprays. The above study shows that the limonene loaded antiemetic formulation can be given via nasal route to enhance the effectiveness as well as onset of action.

Keywords: Limonene, HPMC, DSHOP, Steam distillation method, mucoadhesive polymer, mucoretentive effect.