Abstract

AMELIORATION OF CHEMICAL INDUCED HEPATIC CARCINOGENESIS BY AVERRHOA CARAMBOLA (STAR FRUIT) EXTRACT

Ritu Singh, Jyoti Sharma and P.K. Goyal*

ABSTRACT

The present study is designed to investigate the chemopreventive effect of Averrhoa carambola fruit extract (ACE), a medicinal plant with strong antioxidant properties, in reducing the oxidative stress and hepato-carcinogenesis induced by DENA/CCl4 in mammals. ACE has been trialed with two different doses (15 & 50 mg) against hepatocellular carcinoma (HCC) which was induced after 24 weeks by giving single intra-peritoneal injection of the initiator Diethylnitrosamine (DENA; 15 mg/kg b.wt.) along with the oral administration of promoter carbon tetrachloride (1.6g/kg b.wt. in corn oil thrice a week). DENA caused cent percent tumor incidences with tumor yield scored as 24 ± 4.13. There was a significant (p

Keywords: Hepatocellular carcinoma, DENA, oxidative stress, chemoprevention, Averrhoa carambola extract.