Abstract

FORMULATION AND EVALUATION OF BISOPROLOL FUMARATE OPTIZORB DISPERSIBLE TABLET TO IMPROVE TABLET DISINTEGRATION

B. Lavanya* and V. Shanmugam

ABSTRACT

The present research work was aimed the formulation and evaluation of OptiZorb dispersible tablets of bisoprolol fumarate, an antihypertensive agent. The OptiZorb technology is based on the use of excipients of Alginic acid and calcium carbonate. Alginic acid absorbs lot of water, swells and leads to decay effect brought about. Calcium carbonate reacts with the stomach acid, within 3 minutes it releases 90% of the active ingredient this compared with only 10-15% in marketed paracetamol. Optizorb technology is five times faster in tablet disintegration and thus gets to work much more quickly. Dispersible tablets were prepared by wet granulation method by using Alginic acid and calcium carbonate as disintegrants in different concentrations. Compatibility studies of drug and excipients were carried out by using FT- IR spectroscopy and DSC. The formulations were evaluated for precompressional parameters such as bulk density, tapped density, angle of repose, Carr’s index and Hausner’s ratio. The tablets were evaluated for weight variation, thickness, hardness, friability, drug content, dispersion time, disintegration time and invitro dissolution study. Invitro dissolution studies were performed by using USP dissolution apparatus type II paddle in 900 ml of 0.1N Hydrochloric acid at 50 rpm. No chemical interaction between drug and excipients was confirmed by FTIR studies. After study of all formulations F9 showed short dispersion time with maximum drug release in 15 min and it contains Alginic acid and calcium carbonate (1:1).

Keywords: Alginic acid, antihypertensive, Bisoprolol fumarate, calcium carbonate, dispersible tablet, OptiZorb technology.