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DISPOSITION KINETICS OF CEFQUINOME IN HEALTHY RABBITS FOLLOWING INTRAMUSCULAR AND ORAL ADMINISTRATION
Shalaby, M.A.*; Goudah A.; Gihan M. Kamel and Hassan A. Shaheen
ABSTRACT
The target of the present study was to investigate the serum disposition kinetics of cefquinome, a fourth generation cephalosporin, in healthy rabbits (n = 8) following a single intramuscular (IM) injection and single oral (PO) administration at a dose rate of 10 mg/kg b.wt, using a parallel design single dose study. Blood samples were collected at appropriate times during 24 hrs administration interval. Serum samples were analyzed using High Performance Liquid Chromatography-tandem mass spectrometry (HPLC-MS/MS) method. The serum cefquinome disposition kinetic was best fitted to a two-compartment open model after IM and PO dosage. Following intramuscular and oral administration, the major pharmacokinetic Keywords: Cefquinome; Rabbits; Disposition kinetics; Intramuscular; Oral. [Download Article] [Download Certifiate] |