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EVALUATION OF ANTIDIURETIC EFFECT OF ESCITALOPRAM IN ALBINO WISTAR RATS
Satish A.M, Sibgatullah Md, Pushpa VH, Kalabharathi HL, Kishore MS, Vaibhavi PS
ABSTRACT Introduction: Our study evaluated the antidiuretic action of escitalopram, a SSRIs in albino wistar rats. Materials and Methods: albino wistar rats were divided into 3 groups containing 6 animals each. Standard group received vasopressin, control group received distilled water and test group received escitalopram. The test drug was given for a period of five days. On fifth day diuresis was induced in all the groups of animals by giving frusemide. Urine volume and electrolyte concentration was measured at the end of 5 hour observation period. Results & Discussion: the results suggested significant water retaining capacity of the test drug escitalopram. Further tests are required to confirm the antidiuretic activity of escitalopram in humans. Keywords: Escitalopram, anti diuretic, diuretic cage. [Download Article] [Download Certifiate] |