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World Journal of Pharmacy and
Pharmaceutical Sciences

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Medical Research and Technology

Impact Factor : 8.025

ICV : 84.65

WJPPS Citation

	All	Since 2019
Citation	5450	3969
h-index	23	20
i10-index	134	84

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WJPPS Rank with Index Copernicus Value 84.65 due to high reputation at International Level

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WJPPS is indexed in Scope Database based on the recommendation of the Content Selection Committee (CSC).

WJPPS: NOVEMBER ISSUE PUBLISHED

NOVEMBER 2024 Issue has been successfully launched on 1 NOVEMBER 2024.

Abstract

EVALUATION OF ANTIDIURETIC EFFECT OF ESCITALOPRAM IN ALBINO WISTAR RATS

Satish A.M, Sibgatullah Md, Pushpa VH, Kalabharathi HL, Kishore MS, Vaibhavi PS

ABSTRACT

Introduction: Our study evaluated the antidiuretic action of escitalopram, a SSRIs in albino wistar rats. Materials and Methods: albino wistar rats were divided into 3 groups containing 6 animals each. Standard group received vasopressin, control group received distilled water and test group received escitalopram. The test drug was given for a period of five days. On fifth day diuresis was induced in all the groups of animals by giving frusemide. Urine volume and electrolyte concentration was measured at the end of 5 hour observation period. Results & Discussion: the results suggested significant water retaining capacity of the test drug escitalopram. Further tests are required to confirm the antidiuretic activity of escitalopram in humans.

Keywords: Escitalopram, anti diuretic, diuretic cage.

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