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DESIGN, SYNTHESIS OF NOVEL QUINOLINE-4-CARBOXYLIC ACID DERIVATIVES AND THEIR ANTIBACTERIAL ACTIVITY SUPPORTED BY MOLECULAR DOCKING STUDIES.
Yakaiah Erugu, Bhavanarushi Sangepu, Bharath Gandu, Gangagnirao Anupoju,
ABSTRACT
Pfitzinger condensation reaction performed under basic condition, and it provides simple, novel an efficient synthesis of quinoline-4- carboxylic acid derivatives, which were developed by the domain reaction of Isatin and acetophenone in the presence of 33% KOH in ethanol at reflux condition for 12-13 hrs. The major returns of this protocol are excellent yield, operational cleanness and formation of novel quinoline-4-carboxylic acid derivatives. The synthesized compounds were evaluated for antimicrobial activity. The antimicrobial activity against three Gram-negative bacterial strains (E. coli, Klebsiella pneumonia and Pseudomonas aeruginosa), and three Gram-positive bacterial strains (Bacillus subtilis, Bacillus licheniformis and Staphylococcus saureus) of these quinoline-4-carboxylic acid derivatives were determined. Keywords: Isatin, Methylphenyl ketone, Quinoline-4-carboxylic acid derivatives and Pfitzinger reaction. [Download Article] [Download Certifiate] |