Abstract

ANALGESIC AND ANTI-INFLAMMATORY PROPERTIES OF THE ETHYL ACETATE EXTRACT OF CYLICODISCUS GABUNENSIS (MIMOSACEAE) IN RODENTS

*Ba keugni, *F Longo, La Fotio, S kouam Fogue,T Dimo and  Ls Etoundi,

ABSTRACT

This study was undertaken to assess the analgesic and antiinflammatory activities of the ethyl acetate extract of Cylicodiscus gabunensis stem bark (EACg) in mice and rats. For analgesia, acetic acid, formalin, hot plate, and tail immersion tests were selected, while carrageenan, serotonin and histamine tests were carried out for inflammation. The EACg was administered by oral route at the doses of 100, 200, and 400mg/kg. All the doses, were efficient on pain, with a more potent effect at 200 mg/kg (P<0.01) expressing 61.55% of inhibition in the acetic acid test or 63.11 and 87.09 % respectively during the first and the second phase in the formalin test. For the pain induced by thermal stimuli, the plant at 200 mg/kg expressed 73.09% of inhibition during the first hour in the hot plate test and 70.40% in the tail immersion test during the fourth hour. The effect of EACg (200mg/kg) was partially reversed by naloxone (1 mg/kg) in all the analgesic tests. For inflammation, the oedema volume at all the doses, was significantly reduced with 68.21 %; or 87.09 %; and 87.09 % respectively in the carrageenan, serotonin and histamine tests (one hour post dosing) at the dose of 200mg/kg(P<0.01). These results suggest that the EACg may have components that interact with opioid receptors, or serotonin and histamine pathways. The results from phytochemical analysis indicated the presence of compounds such as flavonoids, alkaloids, saponins, and tannins, which may be responsible of the properties of the extract.

Keywords: Cylicodiscus gabunensis, flavonoids, alkaloids, saponins, and tannins.