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EFFECT OF AN ISOLATED COMPOUND (AS-1) FROM AMARANTHUS SPINOSUS LINN. LEAVES ON SERUM LIPIDS IN NORMAL AND DIABETIC RATS
1Department of Biochemistry, 2. Department of Physiology, North Bengal Medical College, Sushrutanagar – 734012. Dist.Darjeeling, West Bengal, India.
ABSTRACT An active compound (AS-1) was isolated from leaves of Amaranthus spinosus Linn.. The compound was given orally in low (30 mg/kg) and high (60 mg/kg) doses to normal and diabetic rats for two weeks. Diabetes in rats was induced by alloxan. Serum lipids like cholesterol, triglycerides, HDL, LDL and VLDL were estimated. Results showed that the active compound (AS-1) produced a significant fall in serum cholesterol, triglycerides, LDL and VLDL in normal rats. In diabetic rats AS-1 increased HDL cholesterol but decreased the raised levels of serum cholesterol, triglycerides, LDL and VLDL. Keywords: Amaranthus spinosus Linn., serum lipids, isolated compound (AS-1), alloxan, diabetes. [Download Article] [Download Certifiate] |