Abstract

SUSTAINED RELEASE NANOTABLETS OF CATECHIN RICH EXTRACT FOR ENHANCED BIOAVAILABILITY

Monika P, Basavaraj B.V*, Chidambara Murthy K. N, Ahalya N., Indranil Ganguly

ABSTRACT

Catechin is known for its diverse health benefits and poor bioavailability. In the present work catechin rich extract (CRE) has been chosen to develop sustained released nanoparticlesby solvent evaporation technique for enhancing bioavailability. Eudragit L 100 is used as a polymer for formulating CRE into nanoparticles. CRE and polymer were subjected for physical compatibility studies using Fourier transform infrared spectroscopy. Nanoparticles were evaluated for percentage yield, catechin entrapment efficiency and further characterized by SEM, which indicated particles were spherical, nonporous and were in nano-meter range. The X-Ray diffraction and differential scanning calorimetric results suggested that CRE existed as amorphous. Evaluation of pre-compression and post-compression results indicated that, nanotablets had good hardness and flow properties. The results of in vitro release study for nanotablet showed highest drug release of 94.43 % at pH 6.8 (NF1 ) and lowest of 62.20 % was observed for NF3 at pH 7.4.The in vitrorelease data of nanoformulations showed highest correlation for Higuchi matrix, First orderand KorsmeyerPeppas,indicating that the drug release occurred via non-fickian diffusion. Thus, prepared sustained release nanotablets with enhanced bioavailability proved to be a potential oral drug delivery system and based on the results it’s worth considering it for future work.

Keywords: Catechin, bioavailability, Eudragit L 100, sustained release, nanotablets.