Abstract

5-(O-HYDROXY PHENYL)-2-[4’ARYL-3’CHLORO-2’AZETIDINON-1- YL]-1,3,4-THIADIAZOLE; SYNTHESIS AND ANTIBACTERIAL ACTIVITY

Shiv Kumar Gupta*, Pramod Kumar Sharma

ABSTRACT

New series of Disubstituted 1,3,4-Thiadiazoles have been synthesized by the action of the aromatic acid with thiasemicarbazide to obtain the thiadiazoles which are then reflux with the aromatic aldehydes to obtain aminobenzylidine derrivatives of thiadiazoles then it was fused with chloro acetyl chloride in the presence of triethylamine in dioxane with constant stirring to obtained the 5-(o-Hydroxy phenyl)-2-[4’aryl- 3’chloro-2’azetidinon-1-yl]-1,3,4-thiadiazole. The structures of the new compounds were established on the basis of IR, 1H NMR spectral data. In vitro antibacterial activity (MIC activity) was evaluated and compared with standard drugs of Ciprofloxacin. Compounds 3B in the series has shown interesting antibacterial activity against both Gram Positive as well as Gram Negative Bacteria. In the gratifying result, most of the compounds were found to have moderate antibacterial activity.

Keywords: Thiadiazoles, ciprofloxacin, antibacterial activity.