Abstract

DNA CLEAVAGE, IN VITRO ANTIMICROBIAL, ANTIFUNGAL, AND ANTICANCER ACTIVITIES OF SCHIFF BASE TRANSITION METAL COMPLEXES DERIVED FROM 4-AMINOANTIPYRINE AND DIHYDROPYRIMIDINONES

D. Mohanambal* and Dr. S. Arul Antony, Rohinichandran

ABSTRACT

A novel series of transition metal complexes of Cu (II), Co (II), and Cr (III) have been synthesized from the Schiff base derived from Biginelli Product and 4-aminoantipyrine. In this study of Ligand and metal chelates were synthesized and they were characterized by analytical, magnetic, Infrared, Electronic, 1HNMR, 13 C NMR and mass spectral study. The antimicrobial screening of the ligand and its complexes have been extensively studied on bacteria like Vibrio spp., Pseudomonas aeroginosa, Vibrio parahaemolytics, Salmonella spp., Aeromonas spp., Klebsiella spp., Proteus spp. and fungi such as, Aspergillus flavus, Pencillium spp., Trichophyton. The DNA cleavage activity of the ligand and its metal complexes were studied by gel electrophoresis method. The MTT bioassay was also carried out to study the in cytotoxicity properties for the ligand and its metal complexes against VERO and Hep2 cell line. The results also indicate that the metal complexes are better antimicrobial agents as compared to the Parent Schiff base ligand and Biginelli product.

Keywords: 4-Aminoantipyrine, Antimicrobial, Anticancer, Cytotoxicity, DNA Cleavage.