Abstract

SYNTHESIS, CHARACTERIZATION AND ANTIMICROBIAL ACTIVITY OF 2-AZETIDINONE DERIVATIVES

Deepika Chandra*, Prem S. Mishra, Dr. S. K. Gupta, Ritu

ABSTRACT

The present research work involves the synthesis of an N- Substituted- 1, 3, 4-oxadiazol-2-yl)-3-chloro-4-phenylazetidin-2-one (a-f) by refluxing substituted (styryl)-N-benzylidene-1, 3, 4-oxadiazol-2-amine in ethanol. The Synthesized compounds were characterized by elemental analysis, FTIR, 1H NMR and Mass spectrum. All the synthesized compounds were screened for antimicrobial activity by cup plate method against gram (+ve) bacterial strain, staphylococcus aureus, Bacillus subtilis, gram (-ve) bacteraial strain, Escherichia coli, Pseudomonas aeruginosa (Gram-negative) & fungal species Candida albicans. Compounds (e) Showed most potent antibacterial activity on both concentrations against Staphylococcus aureus. Compound (a) showed most potent antibacterial activity on both concentrations against Escherichia coli. Compounds (c) showed most potent antibacterial activity on both concentrations against Pseudomonas aeruginosa. Compounds (b) showed most potent antifungal activity on both concentrations against Candida albicans.

Keywords: 2-azetidinone, Antibacterial activity, Antifungal activity.