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DEVELOPMENT AND VALIDATION OF UVSPECTROPHOTOMETRIC METHOD FOR THE ESTIMATION OF NIZATIDINE IN PLASMA.
Mohammad Zameeruddin*, Khurshid I. Molvi, Jameel Ahmed, Shaikh Siraj
ABSTRACT
Simple, precise and cost effective UV spectrophotometric method has been developed for the estimation of nizatidine in plasma. Nizatidine shows λmax at 314.0 nm in plasma. The drug follows Beer-Lambert law in the concentration range of 2.0-20.0 µg/ml with correlation coefficient of 0.998. The method was validated by analytical performance parameters suggested by the international conference on harmonization. All validation parameters were found to be within the acceptable range. The developed method was successfully applied to estimate the amount of nizatidine in plasma. Keywords: Analytical Method, Nizatidine, Plasma, UV-Spectrophotometric Method [Download Article] [Download Certifiate] |