HAPLOIDENTICAL STEM CELL TRANSPLANTATION: AN OVERVIEW AND PRESENT SCENARIO
Meonis Pithawala*and Ruchi Parmar
ABSTRACT
Haploidentiacal stem cell transplantation offers curative approach to
many haematlogical disorders. The technique has evolved in recent
decades because of the immediate donor availability and the possibility
of collection of donor cells for cellular therapy in future. Historically,
posttransplant problems of graft-versus-host-disease (GvHD), relapse
and nonrelapse mortality occurred because of severe infection. The
higher incidence of GvHd was limited by T-cell depletion in the donor
cells. Sever approached have made to overcome non relapse mortality
such as t-cell replete therapy and natural killer cell therapy.
Administration of high-dose of conditioning regimen can be used to
overcome the post-transplant barriers, suggesting that the most
important barriers against haploidentical stem cell transplant can be overcome. Many
strategies need to be performed to overcome the post-transplant barriers due to the
advantages it offers.
Keywords: Haploidentiacal stem cell, posttransplant problems of graft-versus-hostdisease (GvHD).
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