Abstract

SYNTHESIS OF SPIRO COMPOUNDS AS MEDICINAL AGENTS; NEW OPPORTUNITIES FOR DRUG DESIGN AND DISCOVERY. PART I: A REVIEW

Khurshid I. Molvi, Navedul Haque, Bahlul Z. S. Awen, Mohammad Zameeruddin*

ABSTRACT

Spirocyclic compounds isolated from plant and animal origin has important applications in medicinal chemistry. The tetrahedral nature of the spirolinked carbon rendered it important conformational features and structural implications for biological systems. Spiro heterocycles have been found to play fundamental roles in biological processes and have exhibited diversified biological activity and pharmacological and therapeutical properties. Spirocyclic compounds have fascinated chemists for more than a century. Many methods have been reported for the synthesis of spirocyclic compounds, however we decided to present a representative synthetic scheme of various classes belongs to heterocyclic ring systems in a conventional arrangement. The creation of stereogenic quaternary C centers is a challenging task in organic chemistry, because of their ability to generate a surrounding asymmetrical space in spirans-centres; the syntheses of these spiranscentres have been exploited for asymmetric synthesis, molecular recognition and catalysis in recent years.

Keywords: Azaspirocycles, spiro-?-lactams, spirocyclic compounds, spirocyclic oxetanes, spiroindoles, synthesis.