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COMPARATIVE IN VITRO EVALUATION OF GENERIC CIPROFLOXACIN HYDROCHLORIDE TABLETS
Hamam salih badri hamam
ABSTRACT
Objective: The study was carried out to evaluate the quality of ciprofloxacin tablets sold in retail and wholesale pharmacies in Khartoum, sudan. Methods: The study was done for four different brands of ciprofloxacin (AB1, AB2, AB3 and AB4) obtained from different pharmacies in Khartoum, Sudan from local and international factories .The standard ciprofloxacin obtained from Shangahi-Sudan pharmaceutical. The properties of the tablets were evaluated by some tests in quality control laborataries, namely: uniformity of weight, thickness and diameter, friability, dissolution test and disintegration test. chromatographic method (HPLC) was used to determine the percentage of ciprofloxacin and to assay the tablets. These tests done according to united state pharmacopeia (USP). Results: We found that all the four different manufacturing brands are comply with USP requirements. Conclusion: All the Four brands of the ciprofloxacin hydrochloride tablets evaluated in this study could be regarded as being pharmaceutically and chemically equivalent. Keywords: brands, ciprofloxacin tablets disintegration, dissolution, generic. [Download Article] [Download Certifiate] |