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World Journal of Pharmacy and
Pharmaceutical Sciences

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Medical Research and Technology

Impact Factor : 8.025

ICV : 84.65

WJPPS Citation

	All	Since 2019
Citation	5450	3969
h-index	23	20
i10-index	134	84

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WJPPS Rank with Index Copernicus Value 84.65 due to high reputation at International Level

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WJPPS: NOVEMBER ISSUE PUBLISHED

NOVEMBER 2024 Issue has been successfully launched on 1 NOVEMBER 2024.

Abstract

ANTIVIRAL PROPERTY OF CRUDE AQUEOUS AND ALCOHOLIC EXTRACTS OF ANDROGRAPHIC PANICULATA AGAINST HIV (REVERSE TRANSCRIPTASE) AND HBV (SURFACE ANTIGEN AND DNA POLYMERASE)

Vedha Veerasami¹, Rajendran Paramasivam²,Gnanasekaran Ashok⁴, Murugesan Karthikeyan ⁵, Anushka Shanmugam³, Kannan Mohan⁶, Sri Priya M⁷ and Selvarani P⁸

¹Department of Microbiology, Madras Christian College, Chennai, Tamilnadu, India

²Department of Microbiology, Sri Ramachandra Medical College, Porur, Chennai, T.N. India

³Division of Virology and Immunology, Department of Microbiology, Dr. ALM Post Graduate Institute of Basic Medical Sciences, University of Madras, Chennai, T.N. India.

⁴Biotechnology, Faculty of Integrative Sciences & Technology, Ipoh, Malaysia.

⁵Microbiology Unit, Faculty of Medicine, Quest International University, Perak, Ipoh, Malaysia.

⁶Department of Biotechnology and Research, KVM College of Engineering & Information Technology, Cherthala, Kerala, India.

⁷Department of Microbiology, Karpagam University, Eachanari, Coimbatore, T.N. India.

⁸Department of Microbiology, Govt. Mohan Kumaramangalam Medical College, Salem, Tamil Nadu, India.

ABSTRACT

Plants and plant derived agents have long history as source of potential chemotherapeutic agents in Ayurvedic and Unani system of medicine. The present study has been aimed to study the HIV (Reverse Transcriptase) and HBV (Surface antigen and DNA polymerase by Andrographic paniculata. The plant extract of the Andrographic paniculata has positive inhibitory effect on ethanol.methanol and aqueous extracts of a Andrographic paniculata showed positive inhibition against HIV-RT,HBsAg and HBV DNA Polymerase whereas petroleum ether, hexane and chloroform extracts did not inhibit both HIV and HBV . This is probably the first authentic scientific antiviral report from South India on Andrographic paniculata.Further investigations on the phytochemical of the compounds and the structure elucidation is imperative to confirm the same.

Keywords: Andrographic paniculata; Immunomodulation; HBV DNA Polymerase; Cytokine.

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