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SYNTHESIS, CHARACTERIZATION AND BIOLOGICAL EVALUATION OF NEW 1, 3, 4-THIADIAZOLE DERIVATIVES OF COUMARINS
Touseef Begum*, Khurshid I. Molvi, Suroor A. Kha
ABSTRACT
The new 7-[(5-{[(Z)-(substitutedphenyl)methylidene]amino}-1,3,4-thiadiazol-2-yl)methoxy]-4-methyl-2H-chromen-2-one Va–n have been synthesized from 7-[(5-amino-1,3,4-thiadiazol-2-yl)methoxy]-4-methyl-2H-chromen-2-one IV. All these compounds have been screened in-vivo for their anti-inflammatory and ulcerogenic activity. Compounds Vb, Vc, Vd and Vl were found to be potent member of this series, which showed 81.38%, 80.58%, 80.05% and 75.27% respectively, inflammation inhibitory activity at a dose of 20 mg kg−1 and 100 mg kg−1 p.o. after 1 hr; while the standard drug, indomethacin, Keywords: Coumarins, Anti-inflammatory activity, Ulcerogenic activity, 1, 3, 4-thiadiazole, Quadrant, Craig plot. [Download Article] [Download Certifiate] |