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BIOEQUIVALENCE OF TWO FORMULATIONS OF CEPHALEXIN IN HUMAN HEALTHY VOLUNTEERS ON (HPLC) TECHNIQUE
Alaa Kamal Jabbar Alhamd*
ABSTRACT
Cephalexin is commercially available in the form of capsules and tablets containing 250mg or 500mg for oral administration. Cephalexin is presently used as the most common antibiotics .Twenty healthy Human volunteers were characterized respected to their pharmacokinetic and bioavailability of two formulations of Cephalexin from two sources of industrial companies after a single dose administration was given orally. A developed procedure is described for determination the concentration levels of Cephalexin in human plasma of healthy volunteers using Reversed phase high performance liquid chromatography (Rp-HPLC) with ODS-C18-DB column at low wave length of UV-visible detection "254nm". An efficient drug Keywords: Cephalexin, Bioequivalence, Rp-HPLC, ODS -DB column. [Download Article] [Download Certifiate] |