Abstract

EXTRACTION AND PHYSICOCHEMICAL CHARACTERIZATION OF NOVEL MUCO- BIOADHESANT BIOPOLYMER OBTAINED FROM THE SEEDS OF MOMORDICA CHARANTIA

Arun Kumar Singh, Anita Singh*, N.V. Satheesh Madhav

ABSTRACT

The development of pharmaceutical dosages form involves various components in addition to the active pharmaceutical ingredients. Biopolymers are choice of research as an additives because of its low cost, natural origin, less toxicity, bio-acceptable, environmental-friendly processing, easily available, biodegradable, better patient compliance, renewable in nature and easily accepted by regulatory authority. The aim of the present investigation was to isolate and characterize the biopolymer obtained from seeds of Momordica charantia Linn belonging to Cucurbitaceae family. The biopolymer was isolated by non solvent addition method and was subjected to various spectral analysis (like IR, 1H NMR, SEM,XRD), thermal analysis micromeritic, preliminary phytochemical analysis and physico-chemical properties along with the acute toxicity. The mucoadhesivity of biopolymer was screened by shear stress method, falling sphere method and rotating basket method and results are compared with the standard. The study revealed that the biopolymer exhibited inbuilt mucoadhesivity, so it can be used as a novel excipient for transmucosal drug delivery system.

Keywords: Mucoadhesive Testing, Momordica Charantia, Acute Toxicity Study, NMR Study, DSC Analysis, PXRD.