Abstract

MATHEMATICAL MODELING ON DRUG RELEASE FROM COLON SITE SPECIFIC DRUG DELIVERY SYSTEMS

Kumbakonam Balachandran Ilango*, Kavimani S

ABSTRACT

Drug release studies from solid dosage forms can be considered among the most investigated topics in pharmaceutical research. The model data used in this paper were obtained from recent research publication of the author. Those were used to predict which model provides the best fit for the site specific colon drug delivery system using okra polysaccharide as a carrier. The formulation WO3 showed optimum release and was quantified for its release equivalence in presence and absence of rat cecal matter. It was predicted by subjecting the dissolution profiles for similarity factor and Rescigno index. The dissolution efficiency and mean dissolution time of matrix tablets were studied. The DDSolver software was used to quantify the drug release. The result showed that the drug release did not follow zero order, diffusion alone and erosion alone but the combination of release mechanisms that was confirmed through the Peppas & Shalin model. The logistic model and Weibull distribution emphasized a sigmoidal dissolution profile which was the characteristic for highly degradable polymer. Hopfenberg empirical equation was appropriately applied to predict the surface-eroding characteristic of the formulation. In this study, drug release was dependent on combination of diffusion, erosion and relaxation of polymer chains. The quantified result of similarity, rescigno index, dissolution efficiency and mean dissolution time showed that the drug release was due to the microbially- triggered mechanism. In this study the appropriate mathematical model for colon specific drug delivery system was identified from the already published work of the author.

Keywords: Okra polysaccharide, DDSolver, drug-release model, dissolution similarity, mean dissolution time, dissolution efficiency