Abstract

FORMULATION, EVALUATION AND OPTIMIZATION OF ORO-DISPERSIBLE TABLET CONTAINING OF METFORMIN HCL

Jitul B Patel*, Akash M Patel, D.R. Tesaj Patel, Prakash B Sathwara

ABSTRACT

To prepare Formulation, evaluation and optimization oro-dispersible tablet of containing Metformin hydrochloride, achieve rapid onset of action due to drug release within short period of time and achieve rapid onset of action due to drug release within short period of time. Attempting to prepare oro-dispersible tablet of Metformin HCl which provide convenience of tablet formulation and allowing easy swallowing as of liquid formulation. It is the first-line drug of choice for the treatment of type 2 diabetes, in particular, in overweight and obese people and those with normal kidney function and having bioavailability 50-60 %. Provides quick onset of action due to rapid dissolution which may improve bioavailability and Increase Patients Compliance. Easy to administer for geriatric, mentally retarded, psychiatric and neurodegerative patients and persons who have swallowing problem (dysphasia).

Keywords: Metformin hydrochloride, dysphasia, oro-dispersible tablet.