Abstract

ANTI DIABETIC ACTIVITY OF AAVARAIVITHAADHI CHOORANAM IN ANIMAL MODELS

P.Thenmozhi*, M.Pitchiah Kumar, V.Velpandian, D. Sandhiya, V.Banumathi

ABSTRACT

In this modern era many chronic diseases are due to this lifestyle modification. One among the disease is the Diabetes mellitus which is a great threat worldwide. Siddha medicine plays an effective role in treating Diabetes mellitus. Aavaraivithaadhi Chooranam a siddha drug taken from the classical siddha literature used in the treatment of diabetes mellitus. The aim of the present study was to screen the drug for its acute toxicity in animal model and anti-diabetic activity in Streptozotozin induced diabetes in animal model Wistar albino rats. The animals were selected randomly and divided into four groups with six animals in each group. Group 1 taken as normal control, group 2 taken as diabetic control, group 3 taken as standard and group 4 taken as test drug Aavaraivithaadhi Chooranam (200mg/kg). The results were tabulated and it reveals the potency of the drug. The blood glucose level was reduced significantly which was almost equal to that of the standard and the body weight was also maintained. Acute toxicity study showed no toxic effect so it revealed the safety of the drug. Thus I conclude that the Siddha herbal formulation Aavaraivithaadhi chooranam is safe, potent and effective drug against diabetes mellitus and its complications.

Keywords: Diabetes Mellitus, Streptozotozin, Anti-Diabetic, Blood glucose level.