Abstract

SYNTHESIS, CHARACTERIZATION AND ANTIMICROBIAL ACTIVITY OF 4-OXO-OXAZOLIDINE DERIVATIVES

Vivek Gupta*, A. Pandurangan

ABSTRACT

A series of N- (2- Pheny l – 4 – oxo - oxazolidine – 3 - y l) 4-acetamidophenoxyacetamide (2a-2l) is synthesized from Schiff bases. Antimicrobial activity of synthesized compounds evaluated by cup-plate method. The chemical structures of synthesized compound were confirmed by means of IR, 1HNMR and MS. All the compounds synthesized showed antimicrobial activity out of which compounds 2c, 2e, 2f and 2l shows good antibacterial activity whereas 2g and 2k shows good antifungal activity. The results obtained here indicated, that ring systems enhances the activity to a considerable extent. Further structural modifications and screening is to be required to confirm the more and still better activity. Paracetamol containing oxazolidine derivatives may be used as anti-inflammatory.

Keywords: Antimicrobial, Oxazolidine, Paracetamol, Schiff bases.