Abstract

STUDIES ON THE EFFECT OF OXIDATIVE STRESS INDUCED BY CHLORPYRIFOS ON ANTIOXIDANT HEPATIC ENZYMES IN RAT

Kanika Aggarwal, Devinder Singh*, S. K. Singla

ABSTRACT

Chlorpyrifos (CPF) is an extensively used organophosphate insecticide for crop protection against pests and also in various public health operations. Many studies reported that enzymatic and non-enzymatic antioxidant may play protective role against CPF induced toxicity in mammals. The aim of present study was to investigate the effect of different doses of CPF on antioxidant enzymes. Male rats were divided into 4 groups; Group I (Control received corn oil); Group II (10 mg CPF/kg b. wt./day); Group III (20 mg CPF/kg b. wt./day) and Group IV (30 mg CPF /kg b. wt./day). Animals were treated for 28 days and then their liver tissue was studied for oxidative stress enzymes. CPF toxicity resulted into significant decrease in the activities of SOD, CATALASE and GR in liver tissue.

Keywords: Chlorpyrifos, SOD, Catalase, GR, Oxidative stress, Antioxidants