Abstract

ROLE OF ENDOGENOUS MEDIATORS IN PEPTIC ULCER- A REVIEW ON STRATEGIES OF PATHOGENESIS AND ULCER HEALING

Manpreet Kaur, Satvinder Kaur*, Amandeep Kaur, Anu Mahajan

ABSTRACT

The pathogenetic mechanisms of different types of peptic ulcer are still unclear. Extensive investigations have been focused on the identification of potential endogenous ulcerogenic mediators involved in gastrointestinal ulceration. These studies areimportant in the development of a better therapeutic agent, either to prevent or tocure peptic ulcer. Several endogenous substances have been identifiedand are reported to be involved in the production of peptic ulcer. These substances were increased during inflammatory responses andtheir actions were reported as vascular dependent and possibly free radicals related. In addition various mediators imparts ulcer healing such as growth factors and NO by a genetically programmed repair process, includes inflammation, cell proliferation, re-epithelialization, formation of granulation tissue, angiogenesis, interactions between various cells, matrix and tissue remodelling, all resulting in scar formation. Thepresent study summarizes the ulcerogenic mechanisms of these substancesinvolved in ulceration and in ulcer healing.

Keywords: Peptic ulcer, ulcerogenic mediators, ulcer healing.