Abstract

PROTECTIVE ACTION OF THE FLAVONOID FROM XANTHOCERAS SORBIFOLIA BUNGE IN GASTRIC ULCER PREVENTION INDUCED BY ETHANOL IN RATS

Qi Shuo, Yan Shi-Kai, Lu Hao, Yang Xiao-Yu, Ren Ke, Dong Xiao-Dan, Chang Xuan, Li Fan, Li Dong,Yang Chuan-Hui.

ABSTRACT

ABSTRACT Objective Flavonoid from Xanthoceras Sorbifolia bunge (FXS) was assayed for their possible overall effect on intact gastric mucosa and their protective properties towards the onset of gastric ulcer induced by ethanol. Main methods The gastroprotective action of FXS in doses of 1.2, 12 and 120 mg/kg was analyzed in the ethanol-induced gastric lesion models in rats. After the treatment, the stomachs of the animals were analyzed. Ulcer index, oxidative stress damage (GSH/ GSSG, SOD and CAT) and cytokines analyses (IL-6, IL-10 and PEG2) of the stomachs were done. Key findings: FXS exerted a very strong antiulcer activity, by decreasing the NOx, GSH/GSSG ratio, CAT activity and IL-6, and increase SOD, MPO activity and IL-10. Significance: Their possible mechanism of action was discussed and due to their many positive properties including antioxidant, anti-inflammatory and gastroprotective activities might represent a cost effective alternative sought for in the treatment of gastric ulcers.

Keywords: Flavonoid from Xanthoceras Sorbifolia bunge, gastric ulcer, ethanol, rat.