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EFFECTS OF HMG-COA REDUCTASE INHIBITORS (SIMVASTATIN AND HERBAL FORMULATION OF ALLIUM SATIVUM) ON LIVER FUNCTION TEST IN PATIENTS WITH TYPE 2 DIABETES MELLITUS RELATED DYSLIPIDEMIA
Naveed Ali Siddiqui, Tahira Perveen, Ambreen, Naheed Akhtar, Arshia Sehar
ABSTRACT Objective: To evaluate the changes in liver function test in patients with diabetic dysplipidemia using international and herbal product of the lipid lowering drug, simvastatin and garlic (Allium sativum). Material and Methods: The study was designed to evaluate the effects of HMG-CoA reductase inhibitors (simvastatin and garlic) on LFT, and to compare the adverse effect of international and herbal product of simvastatin and garlic in patients with diabetic dysplipidemia. The study was conducted at Surgeon Munawar Memorial Hospital, Karachi (2012-2013). Sixty patients with abnormal lipid profile were included in the study (age 30-70 years). Patients were divided into two groups (30 patients each). Group A was orally administered with international product of simvastatin (20 mg)/day for 8 weeks and in group B, patients were orally administered with herbal product of garlic (300 mg)/day for 8 weeks. Results: The total bilirubin, direct bilirubin, ALT, AST, alkaline phosphatase was estimated in the serum of diabetic dyslipidemic patients before and after treatment with international product of simvastatin (20mg/day) and herbal product of garlic (300mg/day). After the treatment serum total bilirubin, direct bilirubin, ALT, AST, alkaline phosphatase were increased in group A and group B did not show any significant change in total bilirubin, direct bilirubin, ALT, AST, alkaline phosphatase. Garlic was well tolerated by the subjects without any serious side effects as compared to simvastatin. Conclusion: On the basis of this study it is concluded that garlic was well tolerated by the subjects without any serious side effects as compared to simvastatin. Keywords: LFT, Dysplipidemia, Herbal & International product, Simvastatin & Garlic. [Download Article] [Download Certifiate] |