Abstract

“THE IMPACT OF ANTIDIABETIC THERAPIES ON COGNITIVE FUNCTION AND BRAIN HEALTH”

Jay S. Thakare*, Neha L. Zod, Harigopal S. Sawarkar, Nikita V. Mahalle and Umesh R. Bansod

ABSTRACT

Diabetes mellitus is a metabolic disorder associated with cognitive decline and increased risk of neurodegenerative diseases. Antidiabetic therapies aim to improve glycemic control, but their effects on cognitive function and brain health are not fully understood. The main objective is to conduct a thorough analysis of the available data regarding how antidiabetic medications affect the brain health and cognitive performance of diabetics. Included were studies that looked at how antidiabetic drugs affected neurodegenerative disease risk, neuroimaging results, and cognitive performance. Our review of studies found that certain antidiabetic therapies, such as metformin, pioglitazone, sulfonylureas, dopamine receptor agonist etc. demonstrated neuroprotective effects and improved cognitive function in individuals with diabetes. Additionally, some studies suggested that antidiabetic therapies may reduce the risk of neurodegenerative diseases, including Alzheimer's disease and dementia. Beyond their ability to lower blood sugar, antidiabetic medications may also improve brain health and cognitive function in diabetics. To clarify the processes behind these effects and to guide therapeutic decision-making, more research is required.

Keywords: antidiabetic therapies, cognitive function, brain health, diabetes, neuroprotection, neurodegenerative diseases.