Abstract

EFFICACY OF NANOPARTICLE-BASED DRUG DELIVERY SYSTEMS FOR CANCER THERAPY

Riddhi U. Raut*, Dr. Priyanka Deventhiran and Sonali Uppalwar

ABSTRACT

Cancer is one of the leading causes of death and morbidity due to its complex pathogenesis. The traditional therapies for cancer include chemotherapy, radiation therapy, targeted therapy, and immunotherapy. However, barriers such as cytotoxicity, poor selectivity, and multidrug resistance pose a serious challenge to the successful treatment of cancer. With the advancement of nanotechnology, the field of cancer diagnosis and therapy has experienced a significant transformation. Because of their unique benefits, which include improved permeability and retention impact, less toxicity, more good stability, and accurate targeting, nanoparticles (sizes ranging from 1 to 100 nm) can beutilized to treat cancer. There are multiple primary classifications for nanoparticles. The unique nanoparticle drug delivery technology makes use of the properties of the tumor and its surroundings. Nanoparticles not only circumvent the limitations of conventional cancer treatment, but also multidrug resistance. Additionally, as new mechanisms of multidrug resistance are identified and investigated, more study is being done on nanoparticles. The therapeutic potential of nanoformulations has created new opportunities for cancer treatment. The majority of research, nonetheless, is restricted to in vivo and in vitro investigations, and the quantity of authorized nanodrugs has not increased significantly over time. Numerous nanoparticle forms, targeting strategies, and approved nanotherapeutics for oncological implications in cancer treatment are included in this review. Additionally, we provide an overview of the advantages, difficulties, and present state of clinical translation.

Keywords: Cancer, Nanoparticle, Targeting strategies, Drug delivery, Personalized Nanomedicine, Smart nanoparticles.