Abstract

CHANDIPURA VIRUS’: A REVIEW OF ITS EPIDEMIOLOGY, DIAGNOSIS, PREVENTION, SYMPTOMS, NEUROPATHOGENESIS

Akanksha Surwase*, Yogini Rathod, Dnyaneshwari Dange, Rutika Jivrak, Sonal
Antapurkar, Shital Antapurkar and Amol Wadhave

ABSTRACT

In recent years, Chandipura Virus (CHPV) has emerged as anencephalitic pathogen and has been associated with several outbreaksin different regions of India. Children under the age of 15 are moresusceptible to natural disease. CHPV is emerging as a major epidemicin Indian state. Serious outbreaks due to this virus have occurred inmany parts of India. To detect this virus, a real – time, one – stepreverse PCR test has been used. CHPV is a negative – sense RNA genethat encodes five different proteins (N, P, M, G and L) P protein playsa vital role in the virus's life cycle, while M protein is lethal in nature.There is no specific treatment available to date, symptomatic treatmentinvolves use of mannitol to reduce brain edema. A Vero cell basevaccine candidate against CHPV was evaluated efficiently as a preventive agent against it.Prevention is the best method to suppress CHPV infection. Containment of diseasetransmitting vectors, maintaining good nutrition, health, hygiene and awareness in rural areaswill help in curbing the menace of CHPV. Thus, to control virus transmission some immensepreventive measures need to be attempted until a good anti-CHPV agent is developed.

Keywords: Chandipura Virus, Distribution of Virus, Cause by, Epidemiology, diagnosis, prevention, symptoms, Neuropathogenesis.