Abstract

FORMULATION AND EVALUATION OF SOLID-LIPID NANOPARTICLES LOADED WITH DRUG ETOPOSIDE

Asiya Shaik*, Dr. Snvl Sirisha and G. Jyothi

ABSTRACT

The aim of this study was to investigate the effectiveness of a strategy based on the development of solid lipid Nanoparticles as an innovative formulation of Etoposide with improved therapeutic efficacy. Etoposide SLNs were prepared by Hot homogenization method. The solubility of drug in different solid lipids was measured. FTIR studies indicated no interaction between drug and lipid. SLN were characterized for particle size, zeta potential, entrapment efficiency and surface morphology. In vitro drug release studies were performed in phosphate buffer of pH 7.4 using dialysis bag diffusion technique. The F5 batch had shown maximum entrapment up to 84.95 % and sustained drug release for 8 h. The scanning electron microscopy and zeta potential study showed formation of good SLN dispersion. In vitro release profiles were biphasic in nature and followed Higuchi model of release kinetics. The stability study showed successful formation of stable SLNs.

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