Abstract

HEPATOPROTECTIVE EFFECT OF ETHANOL EXTRACT OF ECLIPTA ALBA (L.) ON PARACETAMOL INDUCED HEPATOTOXICITY

Sangeeta Mewada, Uzma Khan, Anjali Chouhan, Pooja Sonakpuriya and Deepa
Shrivastava*

ABSTRACT

The liver is a vital organ, essential for several metabolic activities, thebreakdown of hazardous and waste materials, and the elimination ofdangerous compounds from the body. Liver diseases remain asignificant concern for human health. The generation of reactiveoxygen species is an inevitable consequence in aerobic organisms, andtheir elimination occurs at a fundamental level, considering both theirbeneficial physiological roles and detrimental impacts. Eclipta albaproliferates in the uncultivated terrains of Bangladesh, where it isregarded as a weed by agriculturalists. Traditional medicinal systemsin the Indian subcontinent and tribal practitioners regard the plant aspossessing various medicinal properties, commonly employing it forthe treatment of gastrointestinal disorders, respiratory ailments (including asthma), fever,alopecia and premature graying, hepatic disorders (including jaundice), dermatologicalconditions, splenomegaly, and lacerations. This study highlights the extensive ethnomedicinaluse of Eclipta alba to elucidate its phytochemical components and hepatoprotectiveproperties. An experiment has been conducted to assess the hepatoprotective properties of theEclipta albplant in order to validate its traditional therapeutic claims.

Keywords: Liver dysfunction, Hepatoprotective activity, Eclipta alba, Paracetamol induced hepatotoxicity, Wistar albino rats.