Abstract

EFFECT OF ANTIBIOTICS IN THE MANAGEMENT OF DENGUE FEVER: A PROSPECTIVE OBSERVATIONAL STUDY

Mir Mansoor Sultan*, Mohammed Mudabbir, Ayesha Begum, Uzma Sultana and
Kareem Unnisa

ABSTRACT

Dengue fever, caused by the dengue virus and transmitted primarily bythe Aedes mosquito, remains a major public health challenge globally.The current standard of care for dengue fever primarily involvessupportive measures, fluid replacement, and symptomatic relief.However, the empirical use of antibiotics has been a subject ofdiscussion and investigation. The purpose of this study is to conduct adrug utilization review and evaluate the prescription patterns inDengue patients. To assess whether antibiotics has a positive impact onreducing the severity of dengue fever symptoms. To identify and assessthe prescribing patterns in Dengue fever patients. In conclusion, thiscomprehensive study aimed to evaluate the drug regimen and clinicalcharacteristics of 160 Dengue patients. With a diverse studypopulation, including both genders aged 8-67, the research uncoveredsignificant Dengue prevalence in the 8-27 age group, with femalesexhibiting higher susceptibility (64.38%). Fever emerged as the primary symptom, followedby headache, general weakness, and myalgia. The majority of patients experienced a 3-dayhospital stay, while laboratory parameters provided valuable insights into disease severity.Doxycycline emerged as a widely prescribed antibiotic, correlating with reduced hospitalstay, particularly in the 3-day duration. Supportive care, including Pantoprazole,Ondansetron, Paracetamol, and nutritional supplements, played a crucial role. This studyoffers valuable insights into Dengue management, emphasizing the importance of tailoredtreatment approaches based on patient demographics and disease severity. The findings contribute to existing literature, calling for further research to optimize therapeutic strategiesand enhance outcomes for Dengue patients.

Keywords: Dengue fever, Antibiotics, Polypharmacy, Drug-Drug interactions (DDIs), Dengue shock syndrome.