Abstract

EVALUATION OF IN VITRO ANTIULCER ACTIVITY OF ETHANOLIC EXTRACT OF MANSOA ALLIACEA LEAVES

Sumi James*, Aiswarya Babu, Santosh M. Thomas

ABSTRACT

Peptic ulcer is a popular disease affecting millions of people all overthe world. Peptic ulcer occurs in the part of the gastrointestinal tractexposed to gastric acid and pepsin, the stomach and duodenum. Itoccurs when the protective mucus layer that lines the stomach isreduced, alllowing digestive acids to destroy the underlying tissue. Dueto the unpleasant side effects produced by conventional drugs likegastric acid inhibitors, gastric acid neutralizing agents, ulcerprotectives, and anti-Helicobacter pylori agents, there is a need formore effective and safer drugs with fewer side effects for the treatmentof gastro-duodenal ulcers. The study aims to evaluate the in vitroantiulcer activity of the ethanolic extract of Mansoa alliacea leaves.The extract was prepared by Soxhlet extraction. Phytochemicalanalysis was performed to find the presence of ulcer responsivephytoconstituents. In-vitro antiulcer activity was evaluated using AcidNeutralizing Capacity by Fordtran's Titration Model. A control, two doses of standard andtwo doses of plant extract were used for the anti-ulcer screening. From the study performed,Acid Neutralizing Capacity in terms of ml of acid consumed and mmol of H+ consumed werecalculated. Two different doses of leaf extract are compared with control (Distilled water)and with standard (Sodium bicarbonate). The ethanolic extract of Mansoa alliacea showedsignificant acid neutralizing capacity. Statistical analysis was done by one-way analysis ofvariance followed by Tukey’s multiple comparison test. The statistical analysis found that theethanolic leaves extract of Mansoa alliacea has promising antiulcer activity.

Keywords: Antiulcer activity, Mansoa alliacea, Sodium bicarbonate, Acid Neutralizing Capacity, Fordtran's Titration Model.