Abstract

A REVIEW ON ANALYTICAL METHOD DEVELOPMENT AND VALIDATION FOR THE SIMULTANEOUS ESTIMATION OF HYDROCHLOROTHIAZIDE AND FIMASARTAN IN BULK AND ITS PHARMACEUTICLE DOSAGE FORM

Suresh Kumar* and Nirma Chavda

ABSTRACT

Hypertension can be classified into primary and secondary forms. Primary hypertension reports for the wide majority (≥90%) of cases, and poor diet and insufficient physical activity look to be important and clearly reversible environmental causes. For enhanced activity of hypertension, Hydrochlorothiazide and Fimasartan are newer combination in the market, which is effective in High blood pressure. This combination was developed to enhance medication for Stage II Hypertension. This article gives information about totally different analytical method development like spectrophotometric and chromatographic methods reported for Hydrochlorothiazide and Fimasartan for individual and other drug combinations. All reported methods were found to be simple, accurate, economic, precise and reproducible in nature. This Review delivers on latest development in analytical method development for Hydrochlorothiazide and Fimasartan, and there are no methods reported for this combination as per our knowledge.

Keywords: Hydrochlorothiazide, Fimasartan., Analytical Method., Hypertension., Stability, Spectrophotometry.