Abstract

A REVIEW ON VARIOUS APPROACHES FOR DELIVERY OF NARINGIN TO ENHANCE ITS SOLUBILITY, STABILITY AND BIOAVAILABILITY

Satyawrath Kumar* and Naresh Kalra

ABSTRACT

Naringin, a bioactive flavonoid glycoside found in citrus fruits, hasnumerous health benefits, but its therapeutic application is limited byits low bioavailability. Naringin is a naringin glycoside that exhibitspromising potential in the prevention and management of variouschronic diseases such as cardiovascular diseases, neurodegenerativedisorders, and certain cancers, primarily through its antioxidant andanti-inflammatory mechanisms. However, its therapeutic potential islimited due to its low solubility. Various advanced drug deliverysystems, such as nanoparticle-based carriers, phospholipid complexes,co-administration with bioenhancers, and self-emulsifying systems, arebeing explored to improve the bioavailableilability of a poorly watersolublecompound. Nanostructured lipid carriers (NLCs) are anadvanced form of lipid-based delivery systems that are composed ofboth solid and liquid lipids. Nanoparticles, nanostructured liposomes (SLNs), NLCs, GNPs,mesoporous silica nanoparticulates (MSNs) and polymeric micelles (PSMs), are emerging aspromising approaches to improve pharmacokinetics, biocompatibility, and therapeuticefficacy of the bioflavonoids. In this review, we focus on the current state of the art inpharmacological research and development of novel delivery systems based on lipid carrierdelivery systems.

Keywords: Naringin, bioavailability, nanotechology, phospholipid, liposome.