Abstract

FORMULATION AND EVALUATION OF DOMPERIDONE SR PELLETS

Danaboina Priyanka*, Dr. S. Shobha Rani and Dr. Basani Gavaskar

ABSTRACT

Pelletisation technologies are currently receiving a lot of interest sincethey offer a workable way to develop novel medication deliverysystems. It is superior to the traditional dosage form in several ways.Pelletization helps produce 0.5–1.5 mm spherical beads or pellets thatcan be coated to provide modified-release dosage forms. Dopamine hasan absolute bioavailability of just 13–17% or roughly 15%. Significantfirst-pass metabolism in the liver and intestines is the cause of this. Its90% bioavailability when administered intramuscularly, however, isremarkable. When taken orally, domperidone takes 30 to 60 minutes tostart working. After taking a dosage orally, dopamine levels peakapproximately 60 minutes later. Exposure to dopamine risesproportionally for doses between 10 and 20 mg. When doperidone isgiven orally four times a day (every five hours) for four days, levelsincrease two to three times. FTIR analyses demonstrate thecompatibility of the excipient and pure medication. Out of all of them, formulation F9 wasthe most effective, exhibiting continuous release over 12 hours with a cumulative drugrelease of 98.51%. The results of this experiment suggest that the Domperidone SR pelletscould be highly beneficial.

Keywords: Sustained release, Pelletization, Domperidone.