Abstract

THE IMPACT OF LIFESTYLE RELATED FACTORS ON THE HUMAN REPRODUCTIVE SYSTEM USING ZEBRAFISH AS A MODEL FOR FERTILITY RESEARCH

Dr. Purnima Vivek*, Akshada Jadhav, Savani Chawan, Mayuresh Bhamode, Rushikesh Valse and Tanvi Dahake

ABSTRACT

Synthetic chemicals known to cause endocrine disruption are widely present in the environment and can affect humans as well as animals. These chemicals find their way into the environment through various sources. This review puts light on various such chemicals and its effects as endocrine disruptors on fertility in adulthood. These synthetic chemicals are a part of personal care products (toothpaste, sunscreen, makeup, perfume that is fragrance oil, synthetic musk, cosmetic and household product like shampoo, soap, fabric softeners, toilet disinfectant, room freshener, and even joss stick). They consist of phthalic acid esters (PAE’s) consists of diethyl phthalate (DEP), butyl benzyl phthalate (BBP), dibutyl phthalate (DBP), di(2-ethylhexyl) phthalate (DEHP) and parabens and are considered as the primary pollutant. We have examined the research on personal care products that contain phthalates or PAEs on freshwater zebrafish (Danio rerio) model and have presented some important findings posing some negative consequences on its reproductive system. The objective of this work is to present a thorough evaluation of these substances' toxicity in order to increase awareness of the need for more thoughtful and responsible use. This review focuses on results in reproduction problems, involves sperm damage, female middle age unusual reproductive tract, infertility in humans.

Keywords: Phthalates, Zebrafish, Infertility, Endocrine disruptors.