Abstract

PHYTOCHEMICAL INVESTIGATION AND GROWTH INHIBITING EFFECTS OF SALIX ALBA LEAVES AGAINST SOME PATHOGENIC FUNGAL ISOLATES

Mohd Sadiq S. Zarger*, Fehmeeda Khatoon, Nida Akhtar

ABSTRACT

Since ancient times, use of plants as a source of medicines has been the inherent part of life in world. Plant based medicines are the basis of many modern pharmaceuticals used in day today life to cure different kind of illnesses. Salix alba has been used from a long time as medicine. In the Current study an attempt was made to determine Phytochemical Composition and in vitro effects of Methanolic extract of Salix alba leaves against Candida guilliermondii, Candida glabrata and Candida parapsilosis. Preliminary Phytochemical analysis revealed the presence of steroids, alkaloids, Phenols, glycosides and tannins in different concentration. In GC-Mass analysis, the major chemical compounds were Salicyl Alcohol, Linolenic acid, Galactose, 4, 6-O-nonylidene, 4-Acetoxy-3-methoxycinnamic acid, Stearic acid, Stearyl aldehyde. Biological activity was carried out in terms of Minimum Inhibitory Concentration, Filter disc assay and growth curve study. From the data we conclude, Salix alba leaves extract as an option can be used further for safe and efficacious drug for Candidiasis.

Keywords: Salix, Candida, Phytochemicals, Biological Activity, Gas Chromatography-Mass Spectrometry.