Abstract

FORMULATION DEVELOPMENT AND EVALUATION OF NANOPARTICLE DRUG DELIVERY

*Priyanka, Sana Sahil, Firoz Khan, Deepshikha Gunwan and Dr. C. K. Tyagi

ABSTRACT

Traditional oral liquid formulations, such as suspensions, emulsions, and solutions, have a number of drawbacks, including intolerance, larger doses, poor absorption, first-pass effects, and physical or chemical instability. Their drug levels fluctuate, leading to an increased likelihood of side effects and an inability to have a long-lasting impact. Finding innovative carriers that satisfy the perfect specifications of a drug delivery system is therefore critically important. Recently, colloidal drug carriers in the form of nanoparticle delivery systems have been presented. These systems can be tailored to meet the various needs of innovative drug delivery systems. The medication can be released from the nanoparticles via controlled diffusion or erosion from the core across a polymeric membrane or matrix if they are coated with an appropriate polymer. Alternatively,the nanoparticles can be tagged with a ligand to direct the therapeutic moiety to a specific organ or even cell. The solubility and diffusivity of the medication in the polymer membrane become the rate-limiting element in drug release since the membrane coating frequently functions as a barrier. Furthermore, the ionic interaction between the medication and auxiliary components may also have an impact on the drug release rate. The medication release may be gradual with essentially no burst release impact if it is permitted to combine with auxiliary substances to generate a less water soluble complex.

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