Abstract

COMPREHENSIVE EXPLORATION OF GUT MICROBIOTA IN PCOS: FROM EARLY DETECTION AND METABOLIC IMPLICATIONS TO THERAPEUTIC STRATEGIES AND ETHNIC VARIATIONS: A SYSTEMATIC REVIEW

Dr. P. Dhivya Prasath, T. Angelin Grace*, K. Aishwarya and S. Aishwarya

ABSTRACT

This systematic review synthesizes evidence on the role of gut microbiota in polycystic ovary syndrome (PCOS). Findings from various studies indicate that gut dysbiosis significantly impacts PCOS pathophysiology, influencing inflammation, metabolic dysfunction, and reproductive health. Gut microbiota alterations have been linked to chronic inflammation and metabolic disturbances, including insulin resistance and metabolic syndrome, prevalent in PCOS. Notably, specific gut bacteria like Lactobacillus farciminis have been associated with reproductive outcomes such as menstrual irregularities and hyperandrogenism. Probiotic interventions show promise in improvingmetabolic and inflammatory markers, potentially offering therapeutic benefits. Elevated levels of inflammatory markers and gut-derived metabolites, such as conjugated primary bile acids, further highlight the intricate relationship between gut microbiota and hormonal imbalances in PCOS. Future research should explore gut microbiota modulation as a non-invasive treatment approach to manage PCOS symptoms and improve both metabolic and reproductive health outcomes.

Keywords: Probiotics, PCOS, Systematic review, gut microbiota.