Abstract

EXPLORING FECAL MICROBIOTA TRANSPLANTATION: A BREAKTHROUGH IN MANAGING GUT DISORDERS - A NARRATIVE REVIEW

R. Subashini*, J. Subiksha, K. Aishwarya and Raveena Rajesh Kumar

ABSTRACT

The gastrointestinal tract contains a diverse community of over 500 bacterial species, which play a crucial role in maintaining health. Medical interventions like antibiotics can disrupt this balance, leading to dysbiosis and contributing to conditions such as obesity, IBD, and IBS. A promising treatment for Clostridium difficile infection and possibly for other gastrointestinal and systemic disorders is fecal microbiota transplantation. In order to restore the patient's gut microbial balance, fecal matter from a healthy donor is transplanted. Although preliminary data points to FMT's safety and efficacy for CDI, further investigation is required to fully understand its underlying mechanisms, wider therapeutic applications, and long-term safety. Ethical and regulatory issues, such as donor selection, informedconsent, and commercialization, are also important, emphasizing the need for comprehensive guidelines and rigorous clinical trials.This review highlights the promise of Fecal Microbiota Transplantation (FMT) for treating gastrointestinal and systemic disorders, especially recurrent Clostridium difficile infections. It emphasizes the need for further research and comprehensive guidelines to ensure FMT's safety and effectiveness in clinical practice.

Keywords: Fecal Microbiota Transplantation (FMT), Gastrointestinal tract, Gut disorders, Microbiota, Clostridium difficile infection (CDI), Microbial Interference Treatment (MIT), Probiotics.